Okay, I actually don't have any precognitive ability but I might as well have some fun while predicting events in 2011. Lets look into the crystal ball.
Facebook becomes a search engine
The Open Graph is just another type of index. Instead of crawling the web like Google, Facebook lets users do it for them. Facebook is creating a massive graph of data and at some point they'll go all Klingon on Google and uncloak with several bird of prey surrounding search. Game on.
Google buys Foursquare
Unless you've been under a rock for the last 6 months it's clear that Google wants to own local. They're dedicating a ton of resources to Places and decided that getting citations from others was nice but generating your own reviews would be better. With location based services just catching on with the mainstream, Google will overpay for Foursquare and bring check-ins to the masses.
UX becomes more experiential
Technology (CSS3, Compass, HTML5, jQuery, Flash, AJAX and various noSQL databases to name a few) transforms how users experience the web. Sites that allow users to seamlessly understand applications through interactions will be enormously successful.
Google introduces more SEO tools
Google Webmaster Tools continues to launch tools that will help people understand their search engine optimization efforts. Just like they did with Analytics, Google will work hard in 2011 to commoditize SEO tools.
Identity becomes important
As the traditional link graph becomes increasingly obsolete, Google seeks to leverage social mentions and links. But to do so (in any major way) without opening a whole new front of spam, they'll work on defining reputation. This will inevitably lead them to identity and the possible acquisition of Rapleaf.
Internet congestion increases
Internet congestion will increase as more and more data is pushed through the pipe. Apps and browser add-ons that attempt to determine the current congestion will become popular and the Internati will embrace this as their version of Greening the web. (Look for a Robert Scoble PSA soon.)
Micropayments battle paywalls
As the appetite for news and digital content continues to swell, a start-up will pitch publications on a micropayment solution (pay per pageview perhaps) as an alternative to subscription paywalls. The start-up may be new or may be one with a large installed user base that hasn't solved revenue. Or maybe someone like Tynt? I'm crossing my fingers that it's whoever winds up with Delicious.
Gaming jumps the shark
This is probably more of a hope than a real prediction. I'd love to see people dedicate more time to something (anything!) other than the 'push-button-receive-pellet' games. I'm hopeful that people do finally burn out, that the part of the cortex that responds to this type of gratification finally becomes inured to this activity.
Curation is king
The old saw is content is king. But in 2011 curation will be king. Whether it's something like Fever, my6sense or Blekko, the idea of transforming noise into signal (via algorithm and/or human editing) will be in high demand, as will different ways to present that signal such as Flipboard and Paper.li.
What people do will outweigh what people say as retargeting is both more effective for advertisers and more relevant for consumers. Privacy advocates will howl and ally themselves with the government. This action will backfire as the idea of government oversight is more distasteful than that of corporations.
Github becomes self aware
Seriously, have you looked at what is going on at Github? There's a lot of amazing work being done. So much so that Github will assemble itself Voltron style and become a benevolently self-aware organism that will be our digital sentry protecting us from Skynet.